For most common antibiotics, such as amoxicillin, moderate alcohol doesn’t cause a dangerous interaction. But some antibiotics, especially metronidazole and tinidazole, can cause a severe reaction with alcohol, including flushing, vomiting, a racing heart and headache. Even when there’s no direct interaction, alcohol can worsen side effects and slow recovery, so avoiding it while you’re ill is sensible.
Antibiotics to avoid alcohol with completely
| Antibiotic | Why | How long to avoid |
|---|---|---|
| Metronidazole | Disulfiram-like reaction: flushing, nausea, vomiting, palpitations | During treatment and for at least 48 hours after the last dose |
| Tinidazole | Similar reaction | During treatment and for 72 hours after |
| Linezolid | Interacts with tyramine-rich drinks (some beers and wines) | As advised by your prescriber |
Check your patient leaflet: guidance can vary for other antibiotics and combination products.
Antibiotics with cautions
- Doxycycline: heavy drinking may reduce its effectiveness
- Co-trimoxazole: rare reactions reported; caution advised
- Antibiotics that cause dizziness or stomach upset: alcohol can worsen these effects
Antibiotics with no major interaction (in moderation)
Amoxicillin, penicillin, cefalexin, azithromycin and many others don’t have a known dangerous interaction with moderate alcohol. But:
- Alcohol can make you dehydrated and tired
- It can affect sleep and immune function
- It may worsen nausea or diarrhoea
Why the “no alcohol on antibiotics” rule exists
Health workers often advise avoiding alcohol on all antibiotics because it’s simpler, because alcohol can slow recovery, and because some antibiotics do interact. It’s not always because of a dangerous chemical reaction.
Practical advice
- Read the label and ask your healthcare provider
- Avoid alcohol completely with metronidazole and tinidazole, including mouthwashes and medicines containing alcohol
- Don’t skip doses so you can drink
- Rest and hydrate to recover faster
Frequently asked questions
Does alcohol stop antibiotics working?
For most antibiotics, moderate alcohol doesn’t stop them working, though heavy drinking may affect some.
Related reading: Amoxicillin guide · BV treatment
Updated 5 November 2026. Always check the patient leaflet and ask a healthcare provider about your specific medicine.
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